ACTIVE IMMUNIZATION OF MAN WITH TOXOID OF HABU (TRIMERESURUS FLAVOVIRIDIS) VENOM
نویسندگان
چکیده
منابع مشابه
Immunogenicity of a toxoid of Habu (Trimeresurus flavoviridis) venom in various animal species including man.
A mixed toxoid consisting of HR1 and HR2 toxoids derived from Habu (Trimeresurus flavoviridis) venom was examined for immunogenicity in guinea pigs, rabbits, monkeys and human beings. The toxoid produced both anti-HR1 and anti-HR2 in various animals. The immunogenicity of the toxoid was superior to a crude toxoid in both guinea pigs and monkeys. Immunized monkeys showing circulating antitoxin p...
متن کاملBiological and Pathological Studies of Rosmarinic Acid as an Inhibitor of Hemorrhagic Trimeresurus flavoviridis (habu) Venom
In our previous report, rosmarinic acid (RA) was revealed to be an antidote active compound in Argusia argentea (family: Boraginaceae). The plant is locally used in Okinawa in Japan as an antidote for poisoning from snake venom, Trimeresurus flavoviridis (habu). This article presents mechanistic evidence of RA's neutralization of the hemorrhagic effects of snake venom. Anti-hemorrhagic activity...
متن کاملEnhancement of hepatic microsomal aniline hydroxylation by Habu snake (Trimeresurus flavoviridis) venom fractions.
Enhancement of aniline hydroxylation by Habu snake venom was studied in vitro. The fraction which was isolated from Habu venom through column chromatography caused the enhancement of aniline hydroxylation of hepatic microsomes obtained from untreated rats. This fraction was heat stable and free from phospholipase activity. Enhancement of aniline hydroxylation was not clear in crude Habu venom o...
متن کاملImmune response of man to Habu-venom toxoid.
Immune response of man to various Habu-venom toxoids with different potencies was investigated. A linear relationship was observed between circulating anti-HRI and the amount of HRI toxoid used for the basic immunization. A highly purified toxoid was 2.5 times more effective in man than partially purified ones, when compared on the basis of the immunizing unit determined in guinea pigs. Out of ...
متن کاملHeat stable protein with anticoagulant and smooth muscle contractile actions isolated from Habu (Trimeresurus flavoviridis) venom.
The biological activity of a Habu (Trimeresurus flavoiridis) venom fraction with drug-metabolizing enzyme inhibitory action was studied. The venom fraction, which was isolated through Sephadex G-100 gel filtration and cation exchange chromatography on Amberlite CG50, caused an increase of vascular permeability and hemorrhage, but these actions were lost after heating at 70 degrees C for 5 min. ...
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ژورنال
عنوان ژورنال: Japanese Journal of Medical Science and Biology
سال: 1972
ISSN: 0021-5112,1884-2828
DOI: 10.7883/yoken1952.25.47